Congratulations to Marcin for being awarded with the prestigious Forschungskredit of the University of Zurich!
Our work on prostate cancer is published in PNAS!
We modeled prostate cancer initiation using organoids and showed that TIP5 (BAZ2A) is critical for the initiation of PCa of luminal origin mediated by Pten-loss whereas it is dispensable once Pten-loss mediated transformation is established. The order of events matters! Cross-species transcriptomic analyses (patients and murine prostate cancer organoids) revealed a PTEN-loss gene signature that identified a set of aggressive tumors with PTEN deletion, or low PTEN expression, and high-TIP5 expression. This work provides a powerful tool to elucidate prostate cancer mechanisms.
Our review on the regulation of the nucleolus and rRNA gene chromatin during ealy development is now published in Trends in Genetics with a dedicated cover.
Congrats to Cristiana, who won the prize for best PhD poster for her work on the identification of nucleolar associated domains (NADs) at the Epigenesys Conference in London!
Congratulations to Cristiana and her group for the best project proposal at the 3rd NCCR RNA & Disease Summer School (August 26th-30th 2019, Saas-Fee prize)!
Our review in Trends in Genetics “Nucleolus and rRNA Gene Chromatin in Early Embryo Development” is published online
June 24, 2019
Congratulations to Karolina for her successful PhD defense!
Our review in Cells “Genome Organization in and around the Nucleolus” is published
We have been awarded a collaborative grant from the Cancer Research Center Zurich. This collaboration between Jean-Pierre Bourquin group at the University Hospital Zurich and our group aims to elucidate the molecular mechanisms of the transcriptional circuitries controlled by the the chimeric fusion transcription factor TCF3-HLF that drives a lethal leukemia with fatal outcome.
May 20, 2019
Congratulations to Rodrigo for his successful PhD defense!
Congratulations to Rodrigo for the “Poster prize" at the 1st Comprehensive Cancer Center Zürich Scientific Retreat 2019
"Pharmacological targeting of the epigenetic reader TIP5-bromodomain impairs prostate cancer stem cells”
Our second joint lab retreat with the groups of Constance Ciaudo (ETH Zurich) and Ana Marques (University of Lausanne). 3 days full of great science and fun in Diemtigtal, Berner Oberland
Registration for the 3rd NCCR RNA & Disease Summer School is now open
Raffaella Santoro, Constance Ciaudo (ETH Zurich) and Ana Claudia Marques (University of Lausanne) will organize this year the third NCCR RNA & Disease Summer School on "RNA Regulation in Health and Disease: Genome architecture and gene expression - RNA turnover - Epitranscriptomics - Phase separation"
This event will take place in Saas-Fee, Switzerland from August 26th to 30th 2019.
The Summer School provides the opportunity to share ideas and learn from leading scientists in the field - check out the stunning lineup of speakers on the flyer below. The program consists of keynote presentations by invited speakers, workshops in small groups, group discussions lead by the invited speakers, flash talks by participating students and postdocs and plenty of opportunities for networking.