Our Research

 

Our group aims to understand fundamental principles of gene regulation.

 

We are interested in understanding how alterations of epigenetic and chromatin regulatory systems contribute to the susceptibility and development of complex diseases.

We study mechanisms of gene expression at multiple levels, from the local action of epigenetic regulatory factors and long non-coding RNAs to the regulation of genome architecture. We use a combination of molecular biology, cell biology and biochemistry methods combined with epigenomic and transcriptomic high-throughput analyses to unravel the mechanisms underlying stem cell pluripotency, differentiation, reprogramming and cancer initiation/progression and to understand epigenetic regulatory processes in physiological and pathological conditions.